This resource explores how fragmented delivery and financing systems for medical, social, and public health services—often operating in isolation despite serving overlapping populations—can be better coordinated. The study emphasizes the need for novel mechanisms to align these systems to enhance population health outcomes. Panelists, including representatives from the University of Kentucky, Trailhead Institute, New York City Department of Health and Mental Hygiene, and the University of Chicago, discuss approaches to integrating services and governance structures to address social determinants of health in East Harlem.